T-cell receptor and B-cell receptor repertoire analysis in patients with immune-mediated liver disease

T-cell receptor and B-cell receptor repertoire analysis in patients with immune-mediated liver disease - RAIL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34876

Enrollment

Registered

2010-03-02

Start date

2010-03-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Auto-immune liver disease immune-mediated liver disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients diagnosed with the diagnosis of PBC, PSC or IAC (study groups), or AIH or hepatitis C (disease controls) - The diagnosis must be confirmed using the appropriate criteria (see: EASL Clinical Practice Guidelines, J Hepatol 2009;51:237). - Patients need to be 18 years of age or older

Exclusion criteria

Exclusion criteria: Inability to provide informed consent

Design outcomes

Primary

Measure	Time frame
The TCR and BCR-repertoire is the main endpoint of the study.	—

Secondary

Measure	Time frame
To assess the influence of disease activity and treatment on the TCR and BCR repertoire.	—

Countries

Netherlands

Outcome results