The effects of kidney transplantation on circadian rhythm. Focus on sleep and cardiometabolic risks.

The effects of kidney transplantation on circadian rhythm. Focus on sleep and cardiometabolic risks. - Circadian Rhythm In Kidney Transplantation -01 (CRIKT-01)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34859

Enrollment

Registered

2011-01-11

Start date

2011-04-27

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

circadian rhythm kidney transplantation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Kidney recipients: - aged 18-85 yr - living donor transplantation - good understanding of dutch language - informed consent;Kidney donors: - aged 18-85 yr - good understanding of dutch language - informed consent

Exclusion criteria

Exclusion criteria: - use of hypnotics/melatonin during the study - relevant co-morbidity that interferes with participation in the study (e.g. heart failure NYHA class IV, instable AP, pulmonary, psychiatric, neurogic, blindness) - documented sleep apnea - alcohol / drug abuse

Design outcomes

Primary

Measure	Time frame
Primary endpoint: recurrence of the 'dim light melatonin onset (DLMO)' after kidney transplantation. Definition of the DLMO: melatonin concentration peak >4 pg/ml in saliva, between 7 and 12 pm.	—

Secondary

Measure	Time frame
Secondary outcomes are: changes in objective and subjective sleep parameters, changes in circadian body temperature, ambulant blood pressure profile, cardiometabolic parameters and quality of life.	—

Countries

Netherlands

Outcome results