COPD emphysema
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: COPD GOLD 2-4 Suspected pulmonary hypertension. Patients with progressive complains and/or unexplained complains with stable lungfunction or cardiovascular limitations during exercise test in who an RHC is clinical indicated
Exclusion criteria
Exclusion criteria: History of systemic hypertension History of left sided cardiac failure Signs of left ventricular dysfunction and/or valvular disease on Doppler echocardiography made prior to inclusion. Neuromuscular disorders COPD-Exacerbations during last 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Do COPD patients with dynamic hyperinflation have a more impaired response of stroke volume and cardiac output at exercise than COPD patients with a similar GOLD classification without dynamic hyperinflation? - SV using direct Fick method at every level of exercise - Inspiratory capacity (IC) What is the effect of dynamic hyperinflation on right and left ventricular function in COPD? -RV pressure/volume curves derived from RHC (pressure) and cMRI (volumes) What is the effect of dynamic hyperinflation on systemic oxygen delivery and extraction? -Arterial and venous blood samples | — |
Secondary
| Measure | Time frame |
|---|---|
| Does the reduction of dynamic hyperinflation in COPD by Heliox (Helium-Oxygen) inhalation lead to afterload reduction of the right ventricle and by that to improvement of the cardiac output augmentation during exercise? - SV, IC and blood samples during Heliox test - Pressure measuremens of RHC What is the influence of dynamic hyperinflation and stroke volume impairment on the outcomes of the rehabilitation program. - Lung function, exercise capacity, quality of life scores during and after rehabilitation program. | — |
Countries
Netherlands
Outcome results
None listed