Identifying genetic and metabolic risk factors for mild non-specific mental retardation and borderline intellectual functioning in parent offspring trios.

Identifying genetic and metabolic risk factors for mild non-specific mental retardation and borderline intellectual functioning in parent offspring trios. - RISK MR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34844

Enrollment

3000

Registered

2010-12-20

Start date

2011-03-01

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. mild non-specific mental retardation and borderline intelligence 2. mild intellectual disability

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1. borderline intellectual functioning (IQ 70-85) or mild mental retardation (IQ 50-70) 2. age 4-18 years 3. parents are available (at least one) and capable of communication in the Dutch language

Exclusion criteria

Exclusion criteria: 1. major congenital malformation 2. suspicion of a syndrome based on physical examination and/or history, judged by a clinical geneticist 3. a known cause for the mild a-specific MR or borderline intellectual functioning

Design outcomes

Primary

Measure	Time frame
- Genetic variation (Single Nucleotide Polymorphisms, SNPs). - Metabolite concentration in urine and plasma. - IQ as measured by an IQ test.	—

Secondary

Measure	Time frame
Attention and social skills, abnormal child behaviour scores, daily functioning will be measured using questionnaires.	—

Countries

Netherlands

Outcome results