Ethnic differences in body composition and substrate utilization: the effect of physical activity and diet.

Ethnic differences in body composition and substrate utilization: the effect of physical activity and diet. - Body composition and substrate utilization.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34820

Enrollment

Registered

2010-05-28

Start date

2010-05-29

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

substraatmetabolisme en insulineresistentie oxidation of fat protein and carbohydrate substrate metabolism

Interventions

The results from the cross-sectional part will be used for the intervention. For each intervention, ten Asian and 10 Caucasian subjects, matched for body fat percentage will be selected. Hence, ther

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: The study includes healthy subjects with a BMI 20-27 kg/m2, aged 20-40 years, stable body weight in the last three months, not following a diet, not using medications except oral contraceptive and no family history of diabetes.

Exclusion criteria

Exclusion criteria: Subjects with chronic diseases known to affect energy metabolism (energy intake and/or expenditure) and athletes will be excluded. Subjects that meet any of the exclusion criteria for MRI (electronic implants, pacemakers, metal fragments in the eyes, skin or body) will be excluded.

Design outcomes

Primary

Measure	Time frame
The main study parameters for the cross-sectional part are the differences in body composition, fat distribution, energy expenditure and substrate utilisation (including dietary fat oxidation). The main study parameters of the overfeeding-high fat diet intervention are the differences in abdominal fat content, liver fat and intramyocellular lipid content (IMCL) and glucose tolerance. The main study parameters for the sedentary life-style intervention are the differences and changes in gene expression related to in adipogenesis, lipogenesis and lipolysis as well as glucose tolerance.	—

Measure

Time frame

The main study parameters for the cross-sectional part are the differences in body composition, fat distribution, energy expenditure and substrate utilisation (including dietary fat oxidation). The main study parameters of the overfeeding-high fat diet intervention are the differences in abdominal fat content, liver fat and intramyocellular lipid content (IMCL) and glucose tolerance. The main study parameters for the sedentary life-style intervention are the differences and changes in gene expression related to in adipogenesis, lipogenesis and lipolysis as well as glucose tolerance.

—

Secondary

Measure	Time frame
• Differences in physical activity between Asians and Caucasians • Differences in physical fitness between Asians and Caucasians • Differences in adipocyte size between Asians and Caucasians • Differences in blood lipid profiles at baseline and after overfeeding a high fat diet or a sedentary life-style between Asians and Caucasians	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)