Obesity
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy males and females Age 19-60 yrs Obese subjects: BMI >30 kg/m2 Lean controls: BMI 19-25 kg/m2 Stable weight for the last 3 months Caucasian FPG 7.5 mmol/l Negative family history of DM2 (first degree family members)
Exclusion criteria
Exclusion criteria: Use of medication known to affect glucose and/or lipid metabolism History of genetic or psychiatric disease that affects the brain Significant chronic disease Renal or hepatic disease Pregnancy Smoking (current) Alcohol consumption of more than 28 units per week at present or in the past Recent blood donation (within the last 3 months) Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year Contra-indication to MRI scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity of energy sensing machinery, measured from muscle biopsies HPA axis activity, measured by blood sampling HPT axis activity, measured by blood sampling Resting-state networks in the brain, measured by FMRI MRI volumetric measurements of amygdale and hippocampus Fat and glucose oxidation rates measured by indirect calorimetry | — |
Countries
Netherlands
Outcome results
None listed