New Hoorn Study: Cause and consequences of disturbed microcirculation: effects of glucose tolerance status

New Hoorn Study: *Cause and consequences of disturbed microcirculation: effects of glucose tolerance status* - Effects of glucose tolerance on microvascular function

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34753

Enrollment

200

Registered

2010-03-17

Start date

2010-04-01

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. vascular dysfunction 2. pre diabetes related change in microvessels

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: participation in the last measure round of 2006 and written approval for contact in new measure rounds

Exclusion criteria

Exclusion criteria: indication of diabetes (type I or II) and or diagnosed with malignant diseases last 12 months

Design outcomes

Primary

Measure	Time frame
microvascular function (structural by number of baseline capillaries and functional by %recruitment after arterial occlusion using capillary microscopy)	—

Secondary

Measure	Time frame
early signs of atheroscleroses (by IMThickness and distensibility in the carotis using ArtLab echografie) markers of endothelial dysfunction and low grade inflammation (using blood samples and elisa) current glucose tolerance status starting with a one-touch glucose measurement and 3 serum samples at start, afetr 1hr and after 2hrs (an OGTT) Anthropometry: Length, weight and WHratio, skinfolds, whole-body DXA scan, using standard techniques Blood pressure, Systolic and diastolic pressures measured in triplicate in sitting position using in the left upper arm at 5-minute intervals with an oscillometric device Questionnaires: Time/date of measurement, menses. current medication, SES, work status, physical activity, smoking, alcohol, nutrition and mental well-being.	—

Measure

Time frame

early signs of atheroscleroses (by IMThickness and distensibility in the carotis using ArtLab echografie) markers of endothelial dysfunction and low grade inflammation (using blood samples and elisa) current glucose tolerance status starting with a one-touch glucose measurement and 3 serum samples at start, afetr 1hr and after 2hrs (an OGTT) Anthropometry: Length, weight and WHratio, skinfolds, whole-body DXA scan, using standard techniques Blood pressure, Systolic and diastolic pressures measured in triplicate in sitting position using in the left upper arm at 5-minute intervals with an oscillometric device Questionnaires: Time/date of measurement, menses. current medication, SES, work status, physical activity, smoking, alcohol, nutrition and mental well-being.

—

Countries

Netherlands

Outcome results