normale fysiologische stressrespons physiological autonomic stress reactivity
Conditions
Interventions
On each testing day (total: two testing days, day1 : TSST
day 2: placebo
stress test)
1 Telemetry pill
All participants receive and ingest a telemetry pill and attach a skin patch
(Vitalsense Minimitter, size 2.3 x 0.87 cm) on the day of the
TSST, at leas
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adults (18 years or older) who provide written informed consent are eligible for the present study
Exclusion criteria
Exclusion criteria: General exclusion criteria are: - smoking - any psychiatric disorder - any significant medical condition including any gastrointestinal condition that would lead to a contraindication for the telemetric pill - current or past drug use (positive urine screen on the presence of amphetamines (including MDMA), barbiturates, cannibinoids, benzodiazepines, cocaine and opiates) - participation in current psychological or psychopharmacological research - present use of any medication which might influence autonomic response, including benzodiazepines, psychotropics, beta blockers, ACE inhibitors and any hormonal treatment including oral anticonceptives. - women in the follicular phase of the menstrual cycle - lack of fluency in the Dutch language - speech impairments Acute exclusion criteria are: - any acute illness - fever - having a severe cold - recent physical exertion within the last 2 hours - large meals within the last 2 hours - caffein use on the test day - high basal stress level (measured with a STAI state anxiety score over 50, average 34.3 in male students (Ploeg 2000))
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the body temperature reaction in response to the TSST. | — |
Secondary
| Measure | Time frame |
|---|---|
| The Secondary outcome measures are: - heart rate responses after the TSST - saliva cortisol levels in response to the TSST - various stress questionnaire outcomes before and after the TSST - correlation of temperature responses with heart rate, cortisol and stress questionnaires | — |
Countries
Netherlands
Outcome results
None listed