Investigation on white matter integrity in autism with diffusion-weighted magnetic resonance imaging

Investigation on white matter integrity in autism with diffusion-weighted magnetic resonance imaging - White Matter Integrity in Autism

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34688

Enrollment

Registered

2010-04-16

Start date

2011-03-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurosciences Autism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: •Physically healthy males with IQ in the normal range •Between 18 and 55 y.-o. •DSM-IV diagnosis of Autism Spectrum Disorder established by an experienced clinician, and above cut-off scores on the ADOS for participants in the ASD group. •Normal vision and hearing.

Exclusion criteria

Exclusion criteria: •Neurological problems (including epilepsy), •Use of drugs that may influence the task performance. •MR incompatible implants in the body •Claustrophobia •The wish not to be informed of brain abnormalities that may be noticed in the scan •(Suspected) Pregnancy •Red tattoos

Design outcomes

Primary

Measure	Time frame
Diffusion-weighted images will be analyzed to estimate voxelwise diffusion parameters and connectivity distributions, as well as indices of whole brain connectivity. These results, as well as other structural, functional and behavioral parameters, will be compared between healthy individuals and autistic patients by means of standard parametric and nonparametric statistical procedures.	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results