peritoneal dialysis peritoneal vascular abnormalities
Conditions
Interventions
None listed
Sponsors
AMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patients with end stage renal disease starting peritoneal dialysis (PD) (at the moment of catheter implantation) or undergoing preemptive kidney transplantation; 2. Stable prevalent PD patients, free of acute inflammatory conditions and malignancy, undergoing any procedure involving the opening of the peritoneal cavity (kidney transplantation, incidental abdominal condition, PD related problems excluding recent peritonitis (4weeks prior to the measurements), e.g. catheter replacement, catheter removal because of membrane failure); 3. A control group: kidney donors undergoing nephrectomy; 4. Age: 18-60 years
Exclusion criteria
Exclusion criteria: 1. unstable clinical condition 2. smoking 3. recent history of peritonitis (peritonitis less than 4weeks prior to the measurement) 4. use of antioxidants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) The thickness of the peritoneal endothelial glycocalyx (as measured by Orthogonal Polarization Spectroscopy) 2) The thickness of the sublingual endothelial glycocalyx (as measured by Orthogonal Polarization Spectroscopy) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Parameters of peritoneal transport in PD patients 2) Morphological alterations of the peritoneal membrane 3) Glycocalyx constituents (hyaluronan, heparansulphate and syndecan-1) and their regulating enzymes (hyaluronidase and heparanase) in plasma and dialysate | — |
Countries
Netherlands
Outcome results
None listed