Alzheimers disease
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient inclusion criteria: - Patients with Alzheimer's disease - Mentally competent AD patient [Clinical Dementia Rating (CDR) scale 1] - The diagnosis of "probable Alzheimer's disease* should be made according to the NINCDS- ADRDA criteria. - Patients or carers should agree with the study (written informed consent is required form patients or their carers).;Inclusion criteria control group (healthy subjects in group A): - Men or women without cognitive or psychiatric disorders - Mini-Mental State Examination (MMSE) score >= 28
Exclusion criteria
Exclusion criteria: Patient exclusion criteria: - Mentally incompetent AD patient [Clinical Dementia Rating (CDR) scale 2 and 3] - Patients with infection or inflammatory disease less than 1 months ago. - Patients with active malignancy. - Patients with autoimmune disease (e.g. temporal arteritis, polymyalgia rheumatica). - Patients who use immune modulating drugs (e.g. Immunocyanin, interferon gamma, immunoglobulin). - Patients with renal dysfunction (MDRD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Descriptives (gender, age, education level, demographics) - Biochemical biomarkers: neopterin, total amino acid spectrum, HVA, BDNF and S-100B - Comorbidity (CIRS-G) - Drug use - MMSE score, neuropsychological examination and MRI cerebrum - The Clinical Dementia Rating (CDR) scale - Evolution: intercurrent diseases | — |
Secondary
| Measure | Time frame |
|---|---|
| nvt | — |
Countries
Netherlands
Outcome results
None listed