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Association between HMOX1 and HP polymorphisms and joint damage in haemophiliacs

Association between HMOX1 and HP polymorphisms and joint damage in haemophiliacs - HMOX1 and HP polymorphisms in haemophiliacs

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON34673
Enrollment
284
Registered
2010-04-27
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

clotting factor VIII/IX deficiency

Interventions

None listed

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Severe (factor VIII/IX activity

Exclusion criteria

Exclusion criteria: Patients with known HIV positivity.

Design outcomes

Primary

MeasureTime frame
The main parameters that are measured are the length of the (GT)n-repeat in the promoter region of the HMOX1 gene; divided in two groups: n = 25, and the phenotype of Hp; Hp 1-1, Hp 1-2, and Hp 2-2 in relation to radiographic joint damage.—

Secondary

MeasureTime frame
The number of joint bleedings per year as recorded by patients in daily practice and the age of the patients have an effect on joint damage progression and might confound the relation of the length of the (GT)n-repeat or Hp phenotype and joint damage.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)