functionele syndromen chronic fatigue syndrome
Conditions
Interventions
None listed
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Female, non-smoking, age between 20 and 60 years. No medical or psychiatric disorder. Specific for patientgroup: unexplained chronic fatigue lasting more than 6 months.
Exclusion criteria
Exclusion criteria: Indication or diagnosis of any medical or psychiatric disorder. Use of systemic medication. Drugs use in month prior to study. Alcohol abuse in month prior to study. Primary sleep disorder that can account for the fatigue complaints. Pregnancy during or in three months before the study. Occurrence of an infection in the week prior to the study. Experience from earlier research shows that about 50 % of potential participants in the chronic fatigue group will be excluded due to use of systemic medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters are: blood plasma CRP-concentrations; self report of negative mood, fatigue, pain complaints and cognitive complaints; pressure pain parameters; and mental effort during a cognitive task. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are Indoleamine 2,3-dioxygenase-mRNA expression and score on a pain catastrophizing questionnaire. | — |
Countries
Netherlands
Outcome results
None listed