Study of individual N-acetyltransferase 1 activity in persons with contact allergy for para-phenylene diamine (PPD).

Study of individual N-acetyltransferase 1 activity in persons with contact allergy for para-phenylene diamine (PPD). - PPD-allergy and N-acetyltransferase 1 activity.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34651

Enrollment

Registered

2010-06-10

Start date

2010-08-02

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

allergic contact dermatitis contact allergie

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: patients: positive patch test on para-phenylene diamine (PPD) controls: negative patch test on para-phenylene diamine (PPD) and exposure to hairdye in the past

Exclusion criteria

Exclusion criteria: legally incompetent

Design outcomes

Primary

Measure	Time frame
- N-acetyltransferase 1 (NAT-1) activity within subjects allergic to PPD, compared to subjects without a PPD allergy. The NAT-1 activity will be measured in whole blood, in the whole PBMC population and in the CD3+, CD4+ and CD8+ T-cells seperately.	—

Secondary

Measure	Time frame
- Quantification of cytokines in plasma. - Genotyping for the NAT-1 gene and determining the odds ratio of proportional frequencies of NAT-1 variants. - Determining the NAT-1 protein leven in leucocytes/T-cells. - Determining the promotor region methylation status.	—

Countries

Netherlands

Outcome results