Elucidating the pathogenesis of Sjogren's syndrome: Analysis of lower lipbiopsies

Elucidating the pathogenesis of Sjogren's syndrome: Analysis of lower lipbiopsies - Analysis of lower lipbiopsies

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34623

Enrollment

200

Registered

2010-05-19

Start date

2010-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dry mouth Xerostomie

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients having a diagnostic lower lipbiopsie for evaluation xerostomia

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Obtained material will be used to elucidate primarily the B cel pathogenesis of Sjogren's syndrome. Using immunohistochemistry, RNA and protein analysis, the B cell receptor (BCR), T cell receptor (TCR), a B cell stimulating cytokine (A proliferation-inducing ligand, APRIL), and the interaction between different immune cell populations and cytokines will be studied. Whenever enough patientmaterial is obtained, we are also be able to study different subpopulations, based on extra-glandular manisfestations and the severity of salivary gland inflammation.	—

Measure

Time frame

Obtained material will be used to elucidate primarily the B cel pathogenesis of Sjogren's syndrome. Using immunohistochemistry, RNA and protein analysis, the B cell receptor (BCR), T cell receptor (TCR), a B cell stimulating cytokine (A proliferation-inducing ligand, APRIL), and the interaction between different immune cell populations and cytokines will be studied. Whenever enough patientmaterial is obtained, we are also be able to study different subpopulations, based on extra-glandular manisfestations and the severity of salivary gland inflammation.

—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results