Effects of Induced Hypothermia on Respiratory parameters and Immunological function

Effects of Induced Hypothermia on Respiratory parameters and Immunological function - REIM study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34602

Enrollment

Registered

2010-09-20

Start date

2011-03-07

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothermia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For the observational part of the study: - Admission to the ICU after cardio pulmonary resuscitation - Treatment with induced mild hypothermia according to protocol, as part of standard patient care For the case-control part of the study, 2 additional groups will be included: - Mechanically ventilated normothermic, non-infectious patients - Healthy volunteers

Exclusion criteria

Exclusion criteria: Exclusion cirteria are: - No informed consent - Inability to complete 24 hours of hypothermia - Presence of pulmonary fibrosis

Design outcomes

Primary

Measure	Time frame
The main endpoint of this study is P/F ratio as a measure of oxygenation and end tidal CO2 as a measure of ventilation.	—

Secondary

Measure	Time frame
Respiratory: oxygenation index, lung injury score, static compliance, dead space ventilation, oxygen consumption. Immunological: levels of pro-inflammatory chemokines and cytokines (TNF-alpha, Il-1beta, and IL-6, IL-2, IFN-g, IL-8), whole blood stimulation, HLA-DR expression.	—

Countries

Netherlands

Outcome results