preventie van hart-en vaatziekten niet van toepassing
Conditions
Interventions
The intervention in this study consists of daily consumption for 12 weeks of 2
basic yoghurt products (placebo group) or 2 nutrient-enriched yoghurt products
(treatment group).
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Apparently healthy men and postmenopausal women between 45 and 65 years old Subjects of normal body weight and height according to BMI between 23 and 30 kg/m2 Subjects of Caucasian race Subject has given written consent to take part in the study Low vitamin K-status
Exclusion criteria
Exclusion criteria: Subjects with hypertension Subjects with hypercholesterolemia Subjects with (a history of) metabolic or gastrointestinal disease Subjects presenting chronic degenerative and/or inflammatory disease Subjects with (a history) of diabetes mellitus Abuse of drugs and/or alcohol Subjects receiving corticostero*d treatment Subjects using oral anticoagulants and subjects with clotting disorders Subjects using blood pressure lowering medication Subjects using cholesterol-lowering medication Subjects using vitamin K containing multivitamins or vitamin K supplements Subjects consuming high amounts of vitamin K-containing food products Subjects with cow*s milk allergy and lactose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main parameters measured during the study are the undercarboxylated and carboxylated forms of the vitamin K-dependent proteins matrix-gla protein and osteocalcin. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are the levels of V-CAM, ICAM-1, E-selectin, SAA, sPLA-2, CRP, vWF, VEGF, IL-6, TNF-a, total cholesterol, triglycerides, and the lipoproteins HDL-cholesterol and LDL-cholesterol. | — |
Countries
Netherlands
Outcome results
None listed