'Aerobic muscle capacity in patients with Postpoliomyelitis Syndrome'

'Aerobic muscle capacity in patients with Postpoliomyelitis Syndrome' - 'Aerobic muscle capacity in patients with PPS'

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34578

Enrollment

Registered

2010-10-19

Start date

2010-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpoliomyelitis Syndrome PPS

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: - Diagnosis of PPS according to the criteria of March of Dimes (2000)*:;a. A confirmed history of paralytic poliomyelitis characterized by an acute illness with fever and a usually asymmetrically distributed, flaccid paresis of a varying number of muscle groups. Evidence of motor neuron loss on neurological examination with signs of residual weakness, atrophy, loss of tendon reflexes and intact sensation. b. A period of partial or complete functional recovery after acute paralytic poliomyelitis, followed by an interval (usually 15 years or more) of stable neurologic function. c. Gradual or sudden onset of progressive and persistent new muscle weakness or abnormal muscle fatigability (decreased endurance), with or without generalized fatigue, muscle atrophy, or muscle and joint pain. Symptoms persist for at least a year. d. No other medical diagnosis to explain the symptoms. (see p. 14-15 of the protocol);Control Subjects: - Healthy volunteers, matched for age, gender, body weigth and height.;*March of Dimes Birth Defects Foundation. Identifying Best Practices in Diagnosis & Care Warm Springs, GA: March of Dimes International Conference on Post-Polio Syndrome. 2000.

Exclusion criteria

Exclusion criteria: Patients and control subjects: - Disabling co-morbidity influencing outcome parameters (including cardiopulmonary disease like chest pain, arrhythmia, pacemaker, cardiac surgery, severe dyspnoea d*effort or emphysema, epileptic seizures, poorly regulated diabetes mellitus).

Design outcomes

Primary

Measure	Time frame
Variables for peripheral muscle properties include critical torque, fatigue index and slope of torque decline. These will be determined with maximal voluntary contractions and (submaximal) electrically evoked contractions of the knee extensor muscles. Variables for aerobic exercise capacity include power output, VO2 and heart rate at anaerobic threshold. These will be determined during graded exercise testing on a cycle ergometer.	—

Measure

Time frame

Variables for peripheral muscle properties include critical torque, fatigue index and slope of torque decline. These will be determined with maximal voluntary contractions and (submaximal) electrically evoked contractions of the knee extensor muscles. Variables for aerobic exercise capacity include power output, VO2 and heart rate at anaerobic threshold. These will be determined during graded exercise testing on a cycle ergometer.

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Secondary

Measure	Time frame
Multiple measures of muscle strength and muscle activation will be determined: Maximal Voluntary Contraction (MVC), Voluntary Activation (VA), Peripheral Fatigue and Central Fatigue.	—

Countries

Netherlands

Outcome results