high blood pressure hypertension
Conditions
Interventions
A diet with a previously determined amount of salt.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Ambulatory adult subjects aged 18-50 years, normotensives and untreated hypertensives (Stage 1 primary hypertension SBP/DBP 140-159/90-99), with high/low-normal CK, matched for body mass index.
Exclusion criteria
Exclusion criteria: BMI>/= 30 kg/m2, CK not in the lowest or highest population tertile; glucose, lipid spectrum, thyroid, kidney, or liver abnormalities, treated, stage 2 (SBP *160 or DBP *100), or secondary hypertension, (history of) cardiovascular disease including TIA and stroke; CK-increasing drugs including statins; neuromuscular or endocrine disorders; vasculitis; HIV infection; infectious hepatitis; bleeding disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in salt excretion with low vs high serum CK. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in vascular contractility with low vs high serum CK. | — |
Countries
Netherlands
Outcome results
None listed