endothelial dysfunction vascular health
Conditions
Interventions
In the current study we will study the effect of 70g chocolate with a high
flavanol content (CHF), which contains 2.2% flavanols of which 10.5% are
epicatechins. As a control we will use 70g chocola
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Caucasian Male 45-70y BMI between 25 and 32 kg/m2
Exclusion criteria
Exclusion criteria: Urine glucose concentrations outside normal ranges (>0,25 g/l) Fasting blood glucose >7.0 mmol/L) Systolic Bp >160 mmHg or diastolic Bp>100 mmHg Blood Hb values
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular measurements: Flow-mediated dilatation (FMD), Pulse Wave Analysis (PWA) of the radial artery and Blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood hematocrite and complete blood count Plasma epicatechins Peripheral blood mononuclear cell (PBMC) protein and gene expression profiles Cell surface activation markers of white blood cells Plasma markers of endothelial function, inflammation and oxidative stress Urine markers of oxidative stress and kidney function | — |
Countries
Netherlands
Outcome results
None listed