geen specifieke aandoening, door het gebruik van micro-arrays nvt
Conditions
Interventions
Two intervention periods of eight weeks with a isoflavone supplement or a
placebo and a washout period of 8 weeks in between.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: women 45-70 year post-menopausal equol-producing
Exclusion criteria
Exclusion criteria: current use of contraceptives containing hormones current use of hormone replacement therapy current soy product use (more than once a week) current isoflavone supplement use (more than once a week) current use of medication containing sexhormones or sexhormone-triggering compounds current use of anti-inflammatory drugs use of antibiotics in the past 6 months severe heart disease thyroid disorders complete ovarectomy thyroidectomy prior diagnosis of cancer in medical history Alcohol and drug abuse Current smoking habits BMI >35 kg/m2 allergic to soy (products)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is gene-expression measured by micro-arrays. | — |
Secondary
| Measure | Time frame |
|---|---|
| Isoflavone levels in plasma and in spoturine | — |
Countries
Netherlands
Outcome results
None listed