Postprandial FGF-19 response after fat challenge in patients with cholestatic liver disease

Postprandial FGF-19 response after fat challenge in patients with cholestatic liver disease - Postprandial FGF-19 response in cholestatic liver disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34548

Enrollment

Registered

2010-09-17

Start date

2010-06-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary biliary cirrhosis and primary sclerosing cholangitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age 18-75 years old. Primary biliary cirrhosis (12), primary sclerosing cholangitis (12) diagnosed preliminary and independent of this study by liverbiopsy (PBC) or MRI (PSC) and 12 patients with IBD without PSC/PBC. 12 healthy subjects.

Exclusion criteria

Exclusion criteria: Exclusion of other liver diseases, defined as: - HBsAg and HCV-antibodies positive - autoimmune hepatitis (ANA, SMA and AMA positive) - hemochromatosis (abnormal iron-saturation) - no Wilson's disease (abnormal ceruloplasmine) - alcohol intake >2 units/day. Previous ileocecal resection.

Design outcomes

Primary

Measure	Time frame
Plasma levels of FGF-19, plasma markers of bile acid synthesis (as a measure of suppression of Cyp7A1, a hepatic target gene of FGF19)	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results