bronchiolitis luchtwegontsteking
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Children under the age of 13 months that require mechanical ventilation for symptoms of respiratory syncytial virus (RSV) lower respiratory infection, known as the index group. In addition, 3 control populations will included: hospitalized RSV patients who do not require mechanical ventilation, ventilated control patients without infection and non-ventilated control patients without infection
Exclusion criteria
Exclusion criteria: Severe comorbidity, such as any organ dysfunction Any Syndromal abnormality, such as Down Syndrome Any other infection during past 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: (1) expression of inhibitory receptors in peripheral blood and tracheal aspirate, (2) concentration of soluble inhibitory receptors in plasma, nasopharyngeal aspirates and urine. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary objective is to study changes in bacterial carriership during the course of infection, which will be studied in nasopharyngeal swabs on admission and 1 month later. | — |
Countries
Netherlands
Outcome results
None listed