Tryptophan enriched diet to improve affective and cognitive functions in patients with multiple sclerosis

Tryptophan enriched diet to improve affective and cognitive functions in patients with multiple sclerosis - Effects of tryptophan enriched diet in MS patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34520

Enrollment

Registered

2010-10-04

Start date

2010-12-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MS multiple sclerosis

Interventions

We will test the acute effects of a whey protein meal where TRP levels can easily be modified in a dose-dependent manner. On each experimental test session, the subject is given a liquid whey protei

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Diagnosis of multiple sclerosis

Exclusion criteria

Exclusion criteria: 1) Subjects with clinically significant disease other than MS 2) Subjects who have used anti-depressive medication with 6 months before the beginning of the study.

Design outcomes

Primary

Measure	Time frame
The Profile of Mood States (POMS) and the Positive and Negative Affect Scale (PANAS) are used prior, 2h and 4 h after treatment to determine changes in mood. Changes in plasma TRP levels and the TRP/*LNAA ratio will be determined over several hours after intake.	—

Secondary

Measure	Time frame
Attention processes (Trail Making Test, Affective Go/NoGo and Stroop test) and memory functions (affective memory test) are tested 3 h after intake.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)