coronary artery disease
Conditions
Interventions
In case of a postive exercise test, PCI of the laesion of interest will only be
performed when both CFR and FFR are indicative for ischemia.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with a second and/or third coronary lesion in the presence of a successfully treated acute coronary occlusion of another coronary vessel are amendable for inclusion.
Exclusion criteria
Exclusion criteria: - Age under 18 and above 80 yrs. - Cardiogenic shock - Anatomical or anticipated problems for complete percutaneous coronary revascularization i.e. diffuse disease, chronic total occlusion. - Prior or indication for coronary artery bypass grafting (CABG) - Presence of a significant left main coronary artery stenosis (> 50% diameter stenosis) - Renal impairment (e.g. serum creatinine level of more than 130 *mol/L) -Unable to exercise -Ventricular arrhythmias, i.e. sustained ventricular tachycardia (VT) or ventricular fibrillation (VF), more than 48 hours after primary PCI -Severe valvular heart disease requiring cardiac surgery within twelve months -Serious known concomitant disease with a life expectancy of less than one year -Factors making follow-up difficult (e.g. not fixed home or address, psychological instability, drugs or alcohol addiction, etc.). -Current participation in another trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A composite of cardiac death, acute myocardial infarction, recurrent revascularization guided by objective evidence of myocardial ischemia at 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| A composite of all-cause death, myocardial infarction, stroke, severe vascular events, recurrent revascularization guided by objective evidence of myocardial ischemia at 12 months. | — |
Countries
Netherlands
Outcome results
None listed