nocturnal GERD nocturnal heartburn
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Man and woman > 18 years of age - Proven nocturnal GERD (pH 3 % of supine position) - Obese subjects: BMI > 30 kg/m2
Exclusion criteria
Exclusion criteria: - Pre-existent esophageal motility disorders - Proven obstructive sleep apnea with CPAP therapy - Inability to stop medication that affects the motility of the upper gastrointestinal tract (anti-cholinergic drugs, theophylline, calcium blocking agents, opioids)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - nocturnal reflux pattern (supine reflux, number of reflux episodes, LES pressure) - LES pressure during reflux episodes - esophageal clearance | — |
Secondary
| Measure | Time frame |
|---|---|
| Esophageal high resolution manometry - basal LES pressure - gastroesophageal pressure gradient - distal esophageal contractil integral (parameter which quantifies the esophageal contraction) pH-impedance signals - percentage non-acid reflux - bolus transit time - Symptom Association Probability (SAP-score) | — |
Countries
Netherlands
Outcome results
None listed