Single pulse TMS: variability and reproducability of MEP and EEG responses in healthy subjects.

Single pulse TMS: variability and reproducability of MEP and EEG responses in healthy subjects. - TMS response in healthy subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34432

Enrollment

Registered

2010-09-27

Start date

2010-11-24

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy seizures

Interventions

TMS (transcranial magnetic stimulation). The TMS equipment has a maximum output of 1.5 Tesla. The puls duration is 400 microsec. 50 Single TMS pulses will be given to 6 different brain areas (3 in

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: age between 18 and 60 right handed

Exclusion criteria

Exclusion criteria: personal history of epilepsy lesion in the brain hearing problems (possible) pregnancy metal objects in brain/skull cochleair implant, implanted brain electrode or pacemaker severe medical condition take medications that lower the threshold for seizures spinal surgery, drains in spinal cord or ventricles use illegal drugs

Design outcomes

Primary

Measure	Time frame
Our main endpoints are the variability and reproducibility of the MEP and EEG responses during the day, so we will present mean values, standard deviations and amounts of change in the following TMS responses: MEP o Amplitude (mV) o Latency (msec) o Motor threshold (Tesla) EEG response o Amplitude of peaks (microV) o Latencies of peaks (msec)	—

Secondary

Measure	Time frame
EEG response: Additional signal analysis methods, including wavelet analysis of early EEG responses and the spatiotemporal characteristics of the EEG response.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)