joint degeneration osteoarthritis
Conditions
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with medial or lateral tibio-femoral compartmental OA considered for HTO according to regular clinical practice Age 2 Intact knee ligaments Normal range-of-motion, normal stability Maximum flexion limitation of 15 degrees (minimum of 120 degrees flexion pre-operative) Body Mass Index
Exclusion criteria
Exclusion criteria: Mechanic axis-deviation of more than 10 degrees Psychological inabilities or difficult to instruct Not able to undergo MRI examination according to standard checklists Inflammatory or rheumatoid arthritis present or in history Post traumatic fibrosis due to fracture of the tibial plateau Bone-to-bone contact in the joint (absence of any joint space on X-ray) Surgical treatment of the involved knee
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Intrinsic cartilage repair, examined as decrease in 'denuded area's of bone', as determined on quantitative MRI in comparison with own baseline values and with HTO. | — |
Secondary
| Measure | Time frame |
|---|---|
| 2. Cartilage tissue repair over 2 year follow-up compared to baseline by use of queantitative MRI parameters of the same iamges, X-ray evaluation, and biomarker analyses in blood and urine. 3. Clinical effetiveness determined by a questionnaire for pain, other symptoms, function in daily living, function in sports and recreation, and knee related quality of life (KOOS) and a VAS for pain. 4. Indication of costs-effeciveness. | — |
Countries
Netherlands
Outcome results
None listed