adult-onset diabetes type 2 diabetes
Conditions
Interventions
Study 1
During both test days, subjects will ingest a test drink or a placebo drink.
The test drink consists of 82,5 g glucose monohydrate dissolved in 225 ml water
and 25 ml vinegar. The placebo dr
Sponsors
Maastricht University
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male type 2 diabetes patients: -40-70 yrs. -BMI 25-35 kg/m2 -oral blood glucose lowering medication;Male control subjects: -40-70 jr. -BMI 25-35 kg/m2
Exclusion criteria
Exclusion criteria: Exogenous insulin therapy; HbA1c 10.0%; diagnosed impaired renal or liver function; morbid obesity (BMI>35 kg/m2); incident cardiovascular events in the last year (heart attack, stroke, aneurysms). Furthermore, subjects with an ulcus pepticum, ulcus duodeni, ulcus ventriculi and/or oesophagal reflux will be excluded. In addition, subjects using antacids, H-2-receptor blockers, proton pump inhibitors, NSAID*s, and/or prokinetic agents will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter/endpoint • Postprandial plasma glucose concentration • Postprandial plasma insulin concentration • Hyperglycemia (glucose concentration >10mmol/L) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters/endpoints • Energy expenditure (derived from physical activity record) • Dietary intake (derived from dietary record) | — |
Countries
Netherlands
Outcome results
None listed