Which muscles are critical for abnormal posture, balance and gait in patients with FSHD?

Which muscles are critical for abnormal posture, balance and gait in patients with FSHD? - Posture, balance and gait in FSHD patients.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34404

Enrollment

Registered

2010-11-10

Start date

2011-03-10

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

facioscapulohumeral dystrophy / Landouzy-Dejerine syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Diagnosis FSHD based on a positive (family) history, examination, genetically confirmed. - Age between 18-80 years. - Being able to stand independently and walk for ten meters without aids.

Exclusion criteria

Exclusion criteria: - Other neurological or musculoskeletal disorders. - Use of medication affecting balance (e.g. neuroleptics, antidepressants, anticonvulsants).

Design outcomes

Primary

Measure	Time frame
Maximum EMG amplitude, expressed as a percentage of the MVC during isolated contraction, is the primary outcome measure of the posture, balance and gait tasks. For the MRIS measurements, the primary outcome will be the cross-sectional area of the various leg and trunk muscles.	—

Secondary

Measure	Time frame
Posture: the joint angles of the lower back, hips, knees, and ankles in two positions. Gait: gait velocity; spatiotemporal variables (e.g. step lengths and cadence); joint angles and joint torques of the lower back, hips, knees and ankles during the gait cycle. Balance: spatiotemporal variables (e.g. displacement of the centre of mass) joint angles and joint torques. MRI: fatty degeneration on a four point scale proposed by Lamminen (1990).	—

Measure

Time frame

Posture: the joint angles of the lower back, hips, knees, and ankles in two positions. Gait: gait velocity; spatiotemporal variables (e.g. step lengths and cadence); joint angles and joint torques of the lower back, hips, knees and ankles during the gait cycle. Balance: spatiotemporal variables (e.g. displacement of the centre of mass) joint angles and joint torques. MRI: fatty degeneration on a four point scale proposed by Lamminen (1990).

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Countries

Netherlands

Outcome results