Effect of transient high blood glucose on brachial artery function

Effect of transient high blood glucose on brachial artery function - Effect of transient high blood glucose on brachial artery function

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34359

Enrollment

Registered

2010-10-25

Start date

2010-11-15

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular disease endothelial dysfunction

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: male, aged 18+, fasting glucose below 6.1 mmol/l (point-of-care blood test, see E.6, item 2.)

Exclusion criteria

Exclusion criteria: Female Non-compliance with one of the following fasting requirements 12 hours prior to measurement: * Medication * Smoking * Caffeine * Vitamin supplements * Exercise * Food and drinks (only water permitted till 3 hours prior to measurements) Fasting blood glucose level higher than 6.1 mmol/l (point-of-care meter; capillary blood sample).

Design outcomes

Primary

Measure	Time frame
FMD, local brachial artery pressure and cyclic change in diameter (distension) as a function of blood glucose en insulin concentrations.	—

Secondary

Measure	Time frame
Correlations of selected biomarkers of endothelial function with mentioned primary study parameters. Also changes therein as a function of blood glucose en insulin concentrations.	—

Countries

Netherlands

Outcome results