Pituitary failure and cognitive dysfunction after cranial radiotherapy for non- pituitary tumors.

Pituitary failure and cognitive dysfunction after cranial radiotherapy for non- pituitary tumors. - Pituitary failure after cranial radiotherapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34358

Enrollment

150

Registered

2010-08-24

Start date

2011-01-01

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hormone deficiency Hypopituitarism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age above 18 years - Cranial irradiation (end of RT > 6 months earlier) with the hypothalamus and pituitary within the field of irradiation - For the following tumors: • Meningeoma grade I or II • Medulloblastoma • Atrocytoma grade I or II • Oligodendroma grade II • Ependyoma • Dysgerminoma • Pineloma • Chordoma • Chondrosarcoma • Schwanoma • Metastasis of other primary non cerebral tumors • Nasopharyngeal tumors • Prophylactic radiation for stem cell transplantation

Exclusion criteria

Exclusion criteria: - Present medical or psychiatric conditions that impair the fulfillment of study requirements and/or interfere with the evaluation of study objectives by probable independent effects on quality of life or neuropsychological functioning. - Known drug or alcohol abuse. - Life expectancy less than 2 years and/or progressive disease. - Grade III or IV intracerbral tumors

Design outcomes

Primary

Measure	Time frame
Prevalence of Pituitary failure	—

Secondary

Measure	Time frame
Quality of life and cognitive functioning	—

Countries

Netherlands

Outcome results