fMRI onderzoek in gezonde vrijwilligers not applicable
Conditions
Interventions
Intravenous infusion of S(+)-ketamine at 20 mg/70 kg/hr for 1 hour, thereafter
40 mg/70 kg/hr for 1 hour, or an infusion with NaCl 0,9%.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy volunteers age 18-45 right handed naive to Ketanest-S
Exclusion criteria
Exclusion criteria: Obesity (BMI > 30); Significant history of any cardiac or vascular disorder, asthma or other pulmonary disease, major gastrointestinal abnormalities, peptic ulceration, hepatic, neurological, psychiatric, haematological (including bleeding disorders), endocrine, renal, or major genitourinary disease. History of illness, condition or medication use that, in the opinion of the investigator, might interfere with optimal participation, confound the results of the study or pose additional risk in administering S(+)-ketamine to the subject or in making the MRIs History of chronic alcohol or illicit drug use; Unable to refrain from quinine containing products and grapefruit or grapefruit juice from 7 days prior to study start until the last study day. Metal medical devices like pacemakers, knee or hip prosthesis, ear implants, vessel clips, subcutaneous insulin pumps or carries metal particles (e.g. metal splinter in the eye) inside the body. Claustrophobia. Allergy to study medications; Not able to maintain a regular diurnal rhythm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| resting state network (fMRI) | — |
Secondary
| Measure | Time frame |
|---|---|
| arterial spin labeling (fMRI) plasma concentrations of S(+)-ketamine and S(+)-norketamine pain relief side effects | — |
Countries
Netherlands
Outcome results
None listed