At Risk Mental State Psychosis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age 16 to 35 2. Adequate command of the Dutch language to complete the assessment 3. Meeting the criteria for an at risk mental state for psychosis as defined by the Personal Assessment and Crisis Evaluation Clinic (PACE) criteria (Yung et al 1998; Yung et al 2003). An individual meets criteria for the *at risk* mental state if they exhibit one or more of the following: 1) a schizotypal personality disorder or a first degree relative with psychosis plus a recent decline in function* 2) *attenuated* positive psychotic symptoms, like ideas of reference, odd beliefs, magical thinking, or unusual perceptual experiences* and 3) a brief psychotic episode of less than one week duration that resolves without antipsychotic medication.
Exclusion criteria
Exclusion criteria: - Having had a psychotic episode for more than one week - Symptoms relevant for inclusion are explained by a medical disorder or drugs or alcohol dependency - IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome measure is transition status to first- episode psychosis within 24months post study entry. Transition is operationally defined via rating scales, as one of: 1. Abnormal thoughts held with delusional intensity occurring every day for one week or longer 2. True hallucinations in any modality occurring every day for one week or longer 3. Formal thought disorder to the degree of incoherence and/or loose associations occurring every day for one week or longer | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. We will examine exposure to the main environmental factors implicated in psychosis: childhood urbanicity and trauma, ethnicity, adolescent cannabis use, acute stress, social discrimination and social defeat. 2. Level of symptomatology, including depression, positive, negative, and basic symptoms 3. Level of functioning across a range of domains including peer relations, family functioning, vocational, and occupational functioning. The following secondary outcome cut points will be applied: Remission will be defined as at least a 50% reduction in the CAARMS positive symptoms score. Recovery will be defined as at least a 50% reduction in key symptom measures (as above) plus improvement in functioning to premorbid level. | — |
Countries
Netherlands
Outcome results
None listed