Daily variation of serum hepcidin levels in healthy volunteers during a day of iron-free diet and a day of iron free diet + oral iron supplementation: a cross over study

Daily variation of serum hepcidin levels in healthy volunteers during a day of iron-free diet and a day of iron free diet + oral iron supplementation: a cross over study - Iron and diurnal rhythm of hepcidin

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34323

Enrollment

Registered

2010-12-24

Start date

2011-01-10

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IJzerstofwisselingsstoornis Anemia/Iron overload

Interventions

Day 1: The volunteers follow an iron-free diet. Day 2: The volunteers follow an iron-free diet, supplemented with tablets of 65mg ferrousfumarate. 9 samples of blood will be taken.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Between 20-60 years of age Fasted hepcidin levels > detection limit (0.5 nM) Hb within reference range ferritin, TIBC, CRP and ALAT within reference range BMI

Exclusion criteria

Exclusion criteria: Red blood cell transfusions (> 2 units) in history Chemotherapy in history

Design outcomes

Primary

Measure	Time frame
Hepcidin	—

Secondary

Measure	Time frame
Hemoglobin (Hb) Mean Corpuscular Volume (MCV) C-Reactive Protein (CRP) Iron (Fe) Total iron binding capacity (TIBC) Tranferrin Saturation (TS) --> calculated from iron and total iron binding capacity Ferritin Alanine Aminotransferase (ALAT)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)