Left Bundle Branch Block after Transcatheter Aortic Valve Implantation (TAVI)

Left Bundle Branch Block after Transcatheter Aortic Valve Implantation (TAVI) - LBBB-TAVI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34321

Enrollment

Registered

2010-09-02

Start date

2010-09-06

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

conduction disorder of het heart left bundle branch block

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: patients planned/accepted for transcatheter aortic valve implantation

Exclusion criteria

Exclusion criteria: inability to give informed consent

Design outcomes

Primary

Measure	Time frame
1. To compare the extent of reversal of left ventricular remodelling at 3 months and 1 year after a TAVI procedure between patients with a TAVI-induced LBBB and TAVI patients without LBBB. Left ventricular remodelling will be defined using echocardiographic parameters (left ventricular endsystolic diameter, left ventricular ejection fraction, left ventricular mass, global longitudinal and circumferential 2D-strain). 2. To evaluate and compare the immediate and long-term effects of a TAVI-induced and non-TAVI-induced LBBB on the ECG, regional and global 2D-strain profile of the left ventricle in a circumferential and longitudinal direction. 2D-Strain will be measured by post-processing of B-mode echocardiographic images (speckle tracking).	—

Measure

Time frame

1. To compare the extent of reversal of left ventricular remodelling at 3 months and 1 year after a TAVI procedure between patients with a TAVI-induced LBBB and TAVI patients without LBBB. Left ventricular remodelling will be defined using echocardiographic parameters (left ventricular endsystolic diameter, left ventricular ejection fraction, left ventricular mass, global longitudinal and circumferential 2D-strain). 2. To evaluate and compare the immediate and long-term effects of a TAVI-induced and non-TAVI-induced LBBB on the ECG, regional and global 2D-strain profile of the left ventricle in a circumferential and longitudinal direction. 2D-Strain will be measured by post-processing of B-mode echocardiographic images (speckle tracking).

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Secondary

Measure	Time frame
1. To compare the TAVI-induced LBBB ECG profile and 2D-strain pattern to that of patients with spontaneous LBBB in order to discriminate a proximal from distal LBBB. 2. To correlate the ECG profile and 2D-strain of TAVI-induced LBBB with that of CRT patients with LBBB and indicate whether a dyssynchrony caused by TAVI-induced LBBB is likely to respond to CRT. 3. To evaluate the feasibility of 3D-TOE in guiding placement of the aortic tissue valve during TAVI procedure	—

Measure

Time frame

1. To compare the TAVI-induced LBBB ECG profile and 2D-strain pattern to that of patients with spontaneous LBBB in order to discriminate a proximal from distal LBBB. 2. To correlate the ECG profile and 2D-strain of TAVI-induced LBBB with that of CRT patients with LBBB and indicate whether a dyssynchrony caused by TAVI-induced LBBB is likely to respond to CRT. 3. To evaluate the feasibility of 3D-TOE in guiding placement of the aortic tissue valve during TAVI procedure

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Countries

Netherlands

Outcome results