Structural and functional neural correlates of the experience of selfagency in health and schizophrenia

Structural and functional neural correlates of the experience of selfagency in health and schizophrenia - Selfagency and schizophrenia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34317

Enrollment

Registered

2010-08-30

Start date

2010-11-19

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

delusions psychosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: -Do have a DSM-IV diagnosis of schizophrenia -Do not chronically use medication, other than psychiatric medication -Give written informed consent -Do not have a major medical history -Are not in an acute psychotic episode Healthy subjects: -Do not have a psychiatric history -Do not have a first-degree family member with a psychiatric illness with psychotic features. -Do not chronically use medication -Give written informed consent -Do not have a major medical history;Specific for the imaging study: Subjects have to satisfy the following criteria in order to participate in the study: -Do not have a pacemaker -Do not have metal materials in the head (except for dental braces)

Exclusion criteria

Exclusion criteria: All subjects: -Drug or alcohol abuse over a period of six months prior to the experiment -History of closed-head injury -History of neurological illness or endocrinological dysfunction -Unable to give consent;Specific for the imaging study: -Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments) -Claustrophobia

Design outcomes

Primary

Measure	Time frame
Study 1: - Performance of patients on selfagency paradigm compared to controls (off line, i.e. no MRI scanner)) Study 2: - Difference between patients and controls in volume (sMRI) or density (VBM) in selfagency related brain areas. - Finding the areas in healthy controls that are involved when attributing selfagency to one*s own actions using the BOLD signal (fMRI) - Difference between patients and controls in brain activation (BOLD) while doing a selfagency task	—

Measure

Time frame

Study 1: - Performance of patients on selfagency paradigm compared to controls (off line, i.e. no MRI scanner)) Study 2: - Difference between patients and controls in volume (sMRI) or density (VBM) in selfagency related brain areas. - Finding the areas in healthy controls that are involved when attributing selfagency to one*s own actions using the BOLD signal (fMRI) - Difference between patients and controls in brain activation (BOLD) while doing a selfagency task

—

Secondary

Measure	Time frame
Baseline values or parameters which might intervene with the main study parameter (age, gender, years of education, symptoms, level of functioning, medication intake)	—

Countries

Netherlands

Outcome results