Synovial fluid concentrations of PGE-2, CTX-I, CTX-II and COMP in the osteoarthritic temporomandibular joint compared to the knee joint

Synovial fluid concentrations of PGE-2, CTX-I, CTX-II and COMP in the osteoarthritic temporomandibular joint compared to the knee joint - PGE-2, CTX-I, CTX-II and COMP in OA of the TMJ compared to OA of the knee

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34304

Enrollment

Registered

2010-07-14

Start date

2010-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fibrocartilage breakdown osteoarthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy TMJ synovial fluid: - Patients of the UMCG department of Oral and Maxillofacial Surgery - Patients undergoing surgery in the TMJ region with symptom free TMJs - No history of arthropathy - 20-40 years of age;Synovial fluid obtained from TMJs with OA - Patient of the UMCG department of Oral and Maxillofacial Surgery - Patients with OA of the TMJ undergoing arthrocentesis - 20-40 years of age;Synovial fluid obtained from knee joints with OA - Patients of the UMCG department of Orthopaedics - Patients with OA of the knee

Exclusion criteria

Exclusion criteria: Synovial fluid obtained from TMJs - History of surgery in the TMJ region - History or active presence of other rheumatic diseases that could be responsible for secondary osteoarthritis - Severe articular inflammation as confirmed by physical examination - Traumatic lesions of the TMJ - Self reported pregnancy;Synovial fluid obtained from knee joints - History of intra-articular surgery of the knee - History or active presence of other rheumatic diseases that could be responsible for secondary osteoarthritis - Severe articular inflammation as confirmed by physical examination - Traumatic knee lesions - Self reported pregnancy

Design outcomes

Primary

Measure	Time frame
Main parameters of this study are concentrations of PGE-2, CTX-I en II en COMP in synovial fluid of the TMJ and the knee.	—

Secondary

Measure	Time frame
Additionally pain is measured by patients with arthritic joints using a visual analogue scale (VAS) and maximum mouth opening (MMO in mm) in order to investigate the correlation between the measured concentrations and the clinical symptoms.	—

Countries

Netherlands

Outcome results