Postprandial insulin release and the impact on muscle perfusion

Postprandial insulin release and the impact on muscle perfusion - Postprandial muscle perfusion

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34290

Enrollment

Registered

2010-10-15

Start date

2010-11-29

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spiermetabolisme Diabetes (mellitus type 2) Non-insulin dependent diabetes mellitus.

Interventions

All subjects will perform an oral glucose tolerance test (OGTT). After an overnight fast, subjects arrive at the laboratory at 0800 h by car or public transportation after an overnight fast. A cathe

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 20 Healthy male volunteers, aged between 20 and 30 20 Healthy male volunteers, aged between 65 and 80 20 Male volunteers with type 2 Diabetes Mellitus, aged between 65 and 80

Exclusion criteria

Exclusion criteria: cardio vascular history Use of insuline medication

Design outcomes

Primary

Measure	Time frame
Microvascular perfusion expressed in glycocalyx permeability (µm), measured with orthogonal polarisation spectrometry in the oral cavity and capillarization (expressed in numbers of capillaries per fiber type) of muscle tissue obtained from a muscle biopsy.	—

Secondary

Measure	Time frame
glucose concentration Postprandial plasma insulin concentration Hyperglycemia (glucose concentration >10mmol/L) Insulin resistance (expressed as OGIS). Total and fiber specific muscle mass	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)