Functional and structural brain network parameters as prognostic factors in Traumatic Brain Injury (TBI)

Functional and structural brain network parameters as prognostic factors in Traumatic Brain Injury (TBI) - Functional and structural brain network parameters in TBI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34259

Enrollment

180

Registered

2011-03-03

Start date

2011-03-15

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intracranial injury traumatic brain injury

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age >= 18 years and 1 year ago (only applicable to patients) - Physical and cognitive abilities to undertake neuropsychological testing - Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements

Exclusion criteria

Exclusion criteria: - History of severe neurological or somatic disease - Psychiatric diagnosis (current and past) - Neurosurgical operations in past - Chronic alcohol or drug abuse - Everyday smoking - Current use of any psychotropic drug - Penetrating injury to the skull - Pregnancy - Metal objects in or around the body (braces, pacemaker, metal fragments, hearing devices) - Claustrophobia

Design outcomes

Primary

Measure	Time frame
From the functional and structural connectivity networks the following network parameters will be assessed: - Centrality of the removed nodes (regions). Centrality of a node measures how many of the shortest paths between all over node pairs in the network pass through it. - Number of connections between the lesion site and the rest of the brain, that were lost. - Local and nodal efficiency in the remaining network as the measure of its robustness. The global clinical outcome of TBI patients will be evaluated using: - extended Glasgow Outcome Scale (GOSE) - functional independence measurement (FIM) score - neurological examination. A battery of neuropsychological tests will be performed to assess the outcome in: - memory and executive function - attention - intellectual function - speech/language.	—

Measure

Time frame

From the functional and structural connectivity networks the following network parameters will be assessed: - Centrality of the removed nodes (regions). Centrality of a node measures how many of the shortest paths between all over node pairs in the network pass through it. - Number of connections between the lesion site and the rest of the brain, that were lost. - Local and nodal efficiency in the remaining network as the measure of its robustness. The global clinical outcome of TBI patients will be evaluated using: - extended Glasgow Outcome Scale (GOSE) - functional independence measurement (FIM) score - neurological examination. A battery of neuropsychological tests will be performed to assess the outcome in: - memory and executive function - attention - intellectual function - speech/language.

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Secondary

Measure	Time frame
The association between genetic polymorphisms and outcome.	—

Countries

Netherlands

Outcome results