fatty degeneration obesity
Conditions
Interventions
- dopamine depletion by 2-day AMPT administration
- gastric banding procedure (only for obese subjects)
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Female; * Age 18-45 years; * BMI >35 of 18-25 kg/m2; * Caucasian; * Able to provide written informed consent and to comply with all study procedures.
Exclusion criteria
Exclusion criteria: * Currently dependent on any substance including nicotine or cannabis; * Diabetes mellitus and/or dyslipidemia; * Hypertension necessitating more than one type of medication; * Severe neurological or psychiatric disorders (e.g., depression, psychosis, bipolar illness, dementia, or any diseases that require psychotropic medications); * Serious medical illnesses; * Drugs known to influence binding to D2R, including neuroleptics, and methylphenidate; * Clinically significant abnormal laboratory values; * Any disease of the gastrointestinal system, liver, or kidneys which could result in altered metabolism or excretion of the study medication; * Pregnancy or breastfeeding; * Contraindications for MRI scan (claustrofobia, inclusion of metal components in the body, e.g. pacemaker) * Measurements crossing maximum weight and size criteria for MRI and SPECT scanner.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Availability of dopamine D2 receptors (D2R) in the striatum before and after dopamine depletion (difference is baseline dopamine level) - eating behavior - correlations between baseline dopamine level, striatal D2R availability, eating behavior, and BMI | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma and urine measurements on dopaminergic parameters | — |
Countries
Netherlands
Outcome results
None listed