The pathophysiological importance of lower esophageal sphincter distensibility in gastroesophageal reflux disease

The pathophysiological importance of lower esophageal sphincter distensibility in gastroesophageal reflux disease - LES distensibility in GERD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34232

Enrollment

Registered

2010-06-21

Start date

2010-04-09

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heartburn

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 9 GERD patients with a hiatal hernia 9 GERD patients with no hiatal hernia or a hiatal hernia

Exclusion criteria

Exclusion criteria: Surgery of the GI tract other than appendectomy or cholecystectomy Motility disorders of the GI tract leading to delayed gastric emptying or altered intestinal motility Inability to stop the use of medication influencing GI motility for one week Inability to stop the use of proton pump inhibitors for one week

Design outcomes

Primary

Measure	Time frame
Esophagogastric junction distensibility	—

Secondary

Measure	Time frame
Questionnaire scores Rate of TLESRs Rate of reflux LES pressure	—

Countries

Netherlands

Outcome results