postoperatieve gedragsstoornissen na sevoflurane anesthesie emergence delirium
Conditions
Interventions
randomization into two groups:
Group A sevoflurane 1 MAC (2,5 vol.%)
Group B sevoflurane 0,5 MAC (1,25 vol.%)
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: age between 1,5-6 years children scheduled for MRI scan onder general anesthesia no premedication ASA status 1-2 parents who speak Dutch parents present during anesthesia induction written informed consent
Exclusion criteria
Exclusion criteria: Cognitive or emotional developmental disorder, with exception of attention deficite hyperactivity disorder. Use of active ingredients which influence the central nervous system (anticonvulsants) Risk of malignant hyperthermia Hypersensitivity to sevoflurane or propofol Need for premedication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary research question: Is it possible that adapting the amount of sevoflurane, from 1 MAC (2,5 vol%) to * MAC (1,25 vol%) in an MRI scan can reduce the frequency and gravity of ED? | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary research questions: 1.Do the anxiety of the parents (measured by the APAIS), the anxiety of the child at induction (measured by the m-YPAS) and the behaviour (measured by the CBCL 11/2-5) constitute a predictive value for the appearance of ED (measured with the PAED scale)? 2.In case significant ED appears, can this lead to an increase of behavioural disorders (measured by the PHBQ) at 1 day, 1 week en 2 weeks after intervention? | — |
Countries
Netherlands
Outcome results
None listed