fat in blood high cholesterol
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient with metabolic syndrome will have to meet at least three of the following criteria (HTG will be a mandatory criteria). o Central obesity; WC > 94 cm in male and > 80 cm in female o Elevated plasma triglycerides 2.0-6.0 mmol/L o Fasting plasma glucose (FPG)
Exclusion criteria
Exclusion criteria: * BMI >32 * Cardiovascular disease * Current use of the following medications: Heparin, or other blood diluting medication * Hepatic dysfunction * End stage renal disease * History of bleeding or recent surgical intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences between cases and controls for: Plasma cholesterol, triglycerides, LDLc, HDLc, apoAI, apoB, apoCII, apoE, apoCIII, ApoAV and ANGPLT 3 and 4 mRNA expression and protein concentration of LPL, GPIHBP1 and ANGPTL4 in adipose tissue mRNA expression and protein concentration of LPL, GPIHBP1 and ANGPTL4 in muscle tissue Histological examination of adipose tissue using antibodies against LPL, GPIHBP1 and ANGPTL4. Histological examination of muscle tissue using antibodies against LPL, GPIHBP1 and ANGPTL4 | — |
Countries
Netherlands
Outcome results
None listed