Cerebellar dysfunction and its compensation in presymptomatic carriers of dominant ataxia genes

Cerebellar dysfunction and its compensation in presymptomatic carriers of dominant ataxia genes - Cerebellar changes in presymptomatic SCA-carriers

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34216

Enrollment

Registered

2011-01-25

Start date

2012-04-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebellar ataxia coordination diffulties

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Proven mutation in one of the SCA genes Age > 18 years Free of ataxia

Exclusion criteria

Exclusion criteria: Contraindications for MRI scanning (e.g. pacemaker) Epilepsy Other neurological disorders Gait disorder for any reason

Design outcomes

Primary

Measure	Time frame
The various studies that are part of this project focus on demonstrating differences in the: -percentage of conditioned eye blink responses -adaptation to splitbelt gait paradigm -motor cortex excitability -cerebellar modulation of motor cortex excitability -structural connection in cerebellum-motor cortex pathway -brain areas involved in the control of gait	—

Countries

Netherlands

Outcome results