patienten die een epiduraal nodig hebben voor een operatie epidural analgesia
Conditions
Interventions
There are 4 groups of 7 patients. The patients in group 1 will receive no
ropivacaine (10 ml of epidural NaCl 0.9%), the patients in group 2 will receive
50 mg of epidural ropivacaine 7.5 mg/ml, the
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: •ASA class I-II •Age 18-65 years •Patients scheduled for surgery requiring epidural anaesthesia and sedation.
Exclusion criteria
Exclusion criteria: •Patients with a BMI >30. •Participation in a trial on investigational drugs within 3 months prior to the study. •Known history of hepatic, renal disease or other disease as judged by the investigators. •Bleeding or coagulation disorders Patients receiving chronic analgesic therapy. •Patients using β-blockers •Pregnancy or lactation. •Alcohol or drug abuses or history of alcohol/drug abuses. •Documented or suspected soybean protein and/or drug allergy or amide type local anesthetic allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the influence of epidural blockade with ropivacaine on the pharmacokinetics of propofol. To evaluate the influence of epidural blockade with ropivacaine on the pharmacodynamics of propofol. This includes both the sedative and the hemodynamic effects. | — |
Secondary
| Measure | Time frame |
|---|---|
| hemodynamic parameters | — |
Countries
Netherlands
Outcome results
None listed