fatty liver NAFLD
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: BMI 28- 35 Waist circumference >= 88 cm (women), >=102 cm (men)
Exclusion criteria
Exclusion criteria: unstable glyceamic control Thiazolidinediones as hypoglycaemic drug excessive alcohol consumption >2 units or more for men per day and 1 units or more for women per day medication, known to cause steatosis: amiodarone, perhexiline, and DH known liver disease cardiac β-blockers advanced pulmonary or cardiovascular disease orthopedic limitations standard contraindications to exercise testing metallic implants (joint replacement, artificial heart valve, clips) cardiac pacemaker any implanted device (e.g. insulin pump, drug infusion device) claustrophobic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver fat content - Visceral and subcutaneous fat content - Liver enzymes, lipid profile | — |
Secondary
| Measure | Time frame |
|---|---|
| Body weight, waist circumference, hip circumference - BMI - VO2 max | — |
Countries
Netherlands