Investigating changes in the human stretch reflex characteristics with Transcranial Magnetic Stimulation applied in the refractory period between the short and long latency reflex response

Investigating changes in the human stretch reflex characteristics with Transcranial Magnetic Stimulation applied in the refractory period between the short and long latency reflex response - Modulation of stretch reflexes with Transcranial Magnetic Stimulation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34193

Enrollment

Registered

2010-12-06

Start date

2010-12-13

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age between 40-70

Exclusion criteria

Exclusion criteria: cardiac pacemakers; any metal implant within the brain;any medical history of general and local neurological disorders, especially epilepsy; any history of orthopedic problems with the upper extremities; current medication that may influence nervous function.

Design outcomes

Primary

Measure	Time frame
Primary outcome parameter is the amplitude of the M2 response as assessed by EMG activity. Dependents are characteristics of ramp-and-hold stretches and timed TMS pulses. Repeated measures Analysis of Variance will be applied for statistical analysis. Statistical significant differences of 30% in normalized M2 amplitude will confirm CNS modulation of peripheral reflex activity.	—

Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results