gastro-oesophageal reflux disease reflux
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Females and males between 18 and 45 yrs of age * No significant clinical pathology or history of heartburn, regurgitation, dysphagia or chest pain or acid suppressive therapy or any other major abdominal complaints in the last year. No history of signs of pathological changes of the oesophageal mucosa visible with conventional endoscopic examination * BMI
Exclusion criteria
Exclusion criteria: * Clinically significant illness within the 2 weeks prior to inclusion or a suspected/manifest infection according to WHO risk categories 2, 3 or 4, as judged by the investigator * Absence of informed consent * BMI *30 or a body weight * 100 kg * History of clinically significant illness, cardiovascular, respiratory, renal, hepatic, neurological, mental or gastrointestinal, as judged by the investigator * Abnormal ECG as judged by the investigator * History of severe allergy/hypersensitivity or symptoms/signs of ongoing allergy/hypersensivity * History of excessive bleeding or suspected coagulopathy * Prior surgery of the upper GI tract except over sewing of an ulcer * Use of PPI, H2 receptor antagonists, pro-kinetic drugs or need for any medication for gastroesophageal reflux disease * History of drug addiction (including cannabinoids), alcohol abuse or other circumstances which in the investigator*s judgment may compromise the subject*s participation * Inability to comply with study procedures * Involvement in the planning and conduct of the study * Previous enrolment in the present study. * Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To correlate tissue impedance, expressed in Ohm, and degree of dilation of intercellular spaces with electron microscopy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed