The seroepidemiology of mumps in a highly vaccinated population of university students in the Netherlands

The seroepidemiology of mumps in a highly vaccinated population of university students in the Netherlands - Mumps seroepidemiology among students

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34179

Enrollment

250

Registered

2011-01-17

Start date

2011-01-26

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mumps

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Medical students (2nd, 3rd, 4th year) from the LUMC.

Exclusion criteria

Exclusion criteria: No exclusion.

Design outcomes

Primary

Measure	Time frame
In the first analysis, the primary study parameter will be the measured mumps titers in the paired serumsamples in the group that has claimed to have had a clinical mumps infection. As a controle on the natural behaviour of MMR antibody titers after several years, also measles and rubella titers will be measured in the same multiplex ELISA at the RIVM. In a second analysis, the occurence of clinical mumps (based on the questionnaire) and subclinical mumps (based on a similar titerrise as in the group with clinical mumps) is the primary study parameter. In this case, the effect of the mumpstiters on the occurence of mumps will be investigated.	—

Measure

Time frame

In the first analysis, the primary study parameter will be the measured mumps titers in the paired serumsamples in the group that has claimed to have had a clinical mumps infection. As a controle on the natural behaviour of MMR antibody titers after several years, also measles and rubella titers will be measured in the same multiplex ELISA at the RIVM. In a second analysis, the occurence of clinical mumps (based on the questionnaire) and subclinical mumps (based on a similar titerrise as in the group with clinical mumps) is the primary study parameter. In this case, the effect of the mumpstiters on the occurence of mumps will be investigated.

—

Secondary

Measure	Time frame
As secondary parameters the relation between the number of MMR vaccines (0, 1 of 2) will be related to the mumpstiters in the first serum sample.	—

Countries

Netherlands

Outcome results